解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:BACKGROUND:Intellectual Disability (ID) is among the most common global disorders, yet etiology is unknown in ~30% of patients despite clinical assessment. Whole genome sequencing (WGS) is able to interrogate the entire genome, providing potential to diagnose idiopathic patients. METHODS:We conducted WGS on eight chil...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-3671-0
更新日期:2017-05-24 00:00:00
abstract:BACKGROUND:As crucial markers in identifying biological elements and processes in mammalian genomes, CpG islands (CGI) play important roles in DNA methylation, gene regulation, epigenetic inheritance, gene mutation, chromosome inactivation and nuclesome retention. The generally accepted criteria of CGI rely on: (a) %G+...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-3731-5
更新日期:2017-05-24 00:00:00
abstract:BACKGROUND:RNA-Seq is now widely used as a research tool. Choices must be made whether to use paired-end (PE) or single-end (SE) sequencing, and whether to use strand-specific or non-specific (NS) library preparation kits. To date there has been no analysis of the effect of these choices on identifying differentially e...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-3797-0
更新日期:2017-05-23 00:00:00
abstract:BACKGROUND:Previous studies suggest genome structure is largely conserved between Eucalyptus species. However, it is unknown if this conservation extends to more divergent eucalypt taxa. We performed comparative genomics between the eucalypt genera Eucalyptus and Corymbia. Our results will facilitate transfer of genomi...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-3782-7
更新日期:2017-05-22 00:00:00
abstract:BACKGROUND:Transversions (Tv's) are more likely to alter the amino acid sequence of proteins than transitions (Ts's), and local deviations in the Ts:Tv ratio are indicative of evolutionary selection on genes. Whether the two different types of mutations have different effects in non-protein-coding sequences remains unk...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-3785-4
更新日期:2017-05-19 00:00:00
abstract:BACKGROUND:Recent studies have suggested that combinations of multiple epigenetic modifications are essential for controlling gene expression. Despite numerous computational approaches have been developed to decipher the combinatorial epigenetic patterns or "epigenetic code", none of them has explicitly addressed the r...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-3764-9
更新日期:2017-05-12 00:00:00
abstract:BACKGROUND:Litchi (Litchi chinensis Sonn.) is an economically important evergreen fruit tree widely cultivated in subtropical areas. Low temperature is absolutely required for floral induction of litchi, but its molecular mechanism is not fully understood. Leaves of litchi played a key role during floral induction and ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-3747-x
更新日期:2017-05-10 00:00:00
abstract:BACKGROUND:Rumen epithelial tissue plays an important role in nutrient absorption and rumen health. However, whether forage quality and particle size impact the rumen epithelial morphology is unclear. The current study was conducted to elucidate the effects of forage quality and forage particle size on rumen epithelial...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-3726-2
更新日期:2017-05-06 00:00:00
abstract:BACKGROUND:Among viruses, bacteriophages are a group of special interest due to their capacity of infecting bacteria that are important for biotechnology and human health. Composting is a microbial-driven process in which complex organic matter is converted into humus-like substances. In thermophilic composting, the de...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-3729-z
更新日期:2017-05-04 00:00:00
abstract:BACKGROUND:Fungal plant pathogens belonging to the genus Venturia cause damaging scab diseases of members of the Rosaceae. In terms of economic impact, the most important of these are V. inaequalis, which infects apple, and V. pirina, which is a pathogen of European pear. Given that Venturia fungi colonise the sub-cuti...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-3699-1
更新日期:2017-05-02 00:00:00
abstract:BACKGROUND:Genomic characterization of rotavirus (RoV) has not been adopted at large-scale due to the complexity of obtaining sequences for all 11 segments, particularly when feces are used as starting material. METHODS:To overcome these limitations, we developed a novel RoV capture and genome sequencing method combin...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-3714-6
更新日期:2017-04-24 00:00:00
abstract:BACKGROUND:Winter-ulcer Moritella viscosa infections continue to be a significant burden in Atlantic salmon (Salmo salar L.) farming. M. viscosa comprises two main clusters that differ in genetic variation and phenotypes including virulence. Horizontal gene transfer through acquisition and loss of mobile genetic elemen...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-3693-7
更新日期:2017-04-20 00:00:00
abstract:BACKGROUND:The Andean cultivar Paloma is resistant to Mesoamerican and Andean races of Colletotrichum lindemuthianum, the fungal pathogen that causes the destructive anthracnose disease in common bean. Remarkably, Paloma is resistant to Mesoamerican races 2047 and 3481, which are among the most virulent races of the an...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-3685-7
更新日期:2017-04-18 00:00:00
abstract:BACKGROUND:Post-translational modification (PTM) of proteins is central to many cellular processes across all domains of life, but despite decades of study and a wealth of genomic and proteomic data the biological function of many PTMs remains unknown. This is especially true for prokaryotic PTM systems, many of which ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-3676-8
更新日期:2017-04-17 00:00:00
abstract:BACKGROUND:Endogenous small interfering (esi)RNAs repress mRNA levels and retrotransposon mobility in Drosophila somatic cells by poorly understood mechanisms. 21 nucleotide esiRNAs are primarily generated from retrotransposons and two inverted repeat (hairpin) loci in Drosophila culture cells in a Dicer2 dependent man...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-3692-8
更新日期:2017-04-17 00:00:00
abstract:BACKGROUND:Segmental duplications (SDs) commonly exist in plant and animal genomes, playing crucial roles in genomic rearrangement, gene innovation and the formation of copy number variants. However, they have received little attention in most livestock species. RESULTS:Aiming at characterizing SDs across the genomes ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-3690-x
更新日期:2017-04-12 00:00:00
abstract:BACKGROUND:Atlantic cod (Gadus morhua), is known to vary genetically across the North Atlantic, Greenland, and Newfoundland. This genetic variation occurs both spatially and temporally through decades of heavy fishing, and is concentrated in three linkage disequilibrium blocks, previously defined by pedigreed linkage m...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-3660-3
更新日期:2017-03-31 00:00:00
abstract:BACKGROUND:Mitochondrial genomes (mtDNA) of multicellular animals (Metazoa) with bilateral symmetry (Bilateria) are compact and usually carry 13 protein-coding genes for subunits of three respiratory complexes and ATP synthase. However, occasionally reported exceptions to this typical mtDNA organization prompted specul...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-3626-5
更新日期:2017-03-31 00:00:00
abstract:BACKGROUND:Genome rearrangement describes gross changes of chromosomal regions, plays an important role in evolutionary biology and has profound impacts on phenotype in organisms ranging from microbes to humans. With more and more complete genomes accomplished, lots of genomic comparisons have been conducted in order t...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-3655-0
更新日期:2017-03-29 00:00:00
abstract:BACKGROUND:Inferring the microbial interaction networks (MINs) and modeling their dynamics are critical in understanding the mechanisms of the bacterial ecosystem and designing antibiotic and/or probiotic therapies. Recently, several approaches were proposed to infer MINs using the generalized Lotka-Volterra (gLV) mode...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-3605-x
更新日期:2017-03-27 00:00:00
abstract:BACKGROUND:DNA methylation is a key modulator of gene expression in mammalian development and cellular differentiation, including neurons. To date, the role of DNA modifications in long-term potentiation (LTP) has not been explored. RESULTS:To investigate the occurrence of DNA methylation changes in LTP, we undertook ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-3621-x
更新日期:2017-03-23 00:00:00
abstract:BACKGROUND:Cancer is a complex disease driven by somatic genomic alterations (SGAs) that perturb signaling pathways and consequently cellular function. Identifying patterns of pathway perturbations would provide insights into common disease mechanisms shared among tumors, which is important for guiding treatment and pr...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-3494-z
更新日期:2017-03-14 00:00:00
abstract:BACKGROUND:Emerging evidence indicates that plant miRNAs can present within human circulating system through dietary intake and regulate human gene expression. Hence we deduced that comestible plants miRNAs can be identified in the public available small RNA sequencing data sets. RESULTS:In this study, we identified a...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-3502-3
更新日期:2017-03-14 00:00:00
abstract:BACKGROUND:Lysophosphatidic acid acyltransferase (LPAAT) encoded by a multigene family is a rate-limiting enzyme in the Kennedy pathway in higher plants. Cotton is the most important natural fiber crop and one of the most important oilseed crops. However, little is known on genes coding for LPAATs involved in oil biosy...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-3594-9
更新日期:2017-03-01 00:00:00
abstract:BACKGROUND:Cold tolerance is a key determinant of the geographical distribution range of a plant species and crop production. Cold acclimation can enhance freezing-tolerance of plant species through a period of exposure to low nonfreezing temperatures. As a subtropical evergreen broadleaf plant, oil-tea camellia demons...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-3570-4
更新日期:2017-02-28 00:00:00
abstract:BACKGROUND:The floral transition plays a vital role in the life of ornamental plants. Despite progress in model plants, the molecular mechanisms of flowering regulation remain unknown in perennial plants. Rosa chinensis 'Old Blush' is a unique plant that can flower continuously year-round. In this study, gene expressio...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-3584-y
更新日期:2017-02-23 00:00:00
abstract:BACKGROUND:Obesity, the excessive accumulation of body fat, is a highly heritable and genetically heterogeneous disorder. The complex, polygenic basis for the disease consisting of a network of different gene variants is still not completely known. RESULTS:In the current study we generated a BAC library of the obese-p...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-3552-6
更新日期:2017-02-15 00:00:00
abstract:BACKGROUND:Alternative splicing (AS) regulation is extensive and shapes the functional complexity of higher organisms. However, the contribution of alternative splicing to fungal biology is not well studied. RESULTS:This study provides sequences of the transcriptomes of the plant wilt pathogen Verticillium dahliae, us...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-3507-y
更新日期:2017-02-06 00:00:00
abstract:BACKGROUND:In plants carotenoids play an important role in the photosynthetic process and photo-oxidative protection, and are the substrate for the synthesis of abscisic acid and strigolactones. In addition to their protective role as antioxidants and precursors of vitamin A, in wheat carotenoids are important as they ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-3395-6
更新日期:2017-01-31 00:00:00
abstract:BACKGROUND:Deciphering taxonomical structures based on high dimensional sequencing data is still challenging in metagenomics study. Moreover, the common workflow processed in this field fails to identify microbial communities and their effect on a specific disease status. Even the relationships and interactions between...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-3257-2
更新日期:2017-01-25 00:00:00
abstract:BACKGROUND:The expanding number and global distributions of herbicide resistant weedy species threaten food, fuel, fiber and bioproduct sustainability and agroecosystem longevity. Amongst the most competitive weeds, Amaranthus palmeri S. Wats has rapidly evolved resistance to glyphosate primarily through massive amplif...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-3336-4
更新日期:2017-01-17 00:00:00
abstract:BACKGROUND:MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate gene expression by targeting specific mRNA species for degradation or interfering with translation. Specific miRNAs are key regulators of adipogenesis, and are expressed at different levels in adipose tissue from lean and obese mice. The deg...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-3484-1
更新日期:2017-01-17 00:00:00
abstract:BACKGROUND:The food spoilage yeast species Zygosaccharomyces bailii exhibits an extraordinary capacity to tolerate weak acids, in particular acetic acid. In Saccharomyces cerevisiae, the transcription factor Haa1 (ScHaa1) is considered the main player in genomic expression reprogramming in response to acetic acid stres...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-3443-2
更新日期:2017-01-13 00:00:00
abstract:BACKGROUND:Modern broiler chickens exhibit very rapid growth and high feed efficiency compared to unselected chicken breeds. The improved production efficiency in modern broiler chickens was achieved by the intensive genetic selection for meat production. This study was designed to investigate the genetic alterations a...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-3471-y
更新日期:2017-01-13 00:00:00
abstract:BACKGROUND:Nicotiana attenuata (coyote tobacco) is an ecological model for studying plant-environment interactions and plant gene function under real-world conditions. During the last decade, large amounts of genomic, transcriptomic and metabolomic data have been generated with this plant which has provided new insight...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-3465-9
更新日期:2017-01-13 00:00:00
abstract:BACKGROUND:Sugarcane (Saccharum spp.) is predominantly an autopolyploid plant with a variable ploidy level, frequent aneuploidy and a large genome that hampers investigation of its organization. Genetic architecture studies are important for identifying genomic regions associated with traits of interest. However, due t...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-3383-x
更新日期:2017-01-11 00:00:00
abstract:BACKGROUND:Fistular leaves frequently appear in Allium species, and previous developmental studies have proposed that the process of fistular leaf formation involves programmed cell death. However, molecular evidence for the role of programmed cell death in the formation of fistular leaf cavities has yet to be reported...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-3474-8
更新日期:2017-01-10 00:00:00
abstract:BACKGROUND:Colletotrichum graminicola and C. sublineola cause anthracnose leaf and stalk diseases of maize and sorghum, respectively. In spite of their close evolutionary relationship, the two species are completely host-specific. Host specificity is often attributed to pathogen virulence factors, including specialized...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-3457-9
更新日期:2017-01-10 00:00:00
abstract:BACKGROUND:Sorghum [Sorghum bicolor (L.) Moench] is an important cereal crop for dryland areas in the United States and for small-holder farmers in Africa. Natural variation of sorghum grain composition (protein, fat, and starch) between accessions can be used for crop improvement, but the genetic controls are still un...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-3403-x
更新日期:2017-01-05 00:00:00
abstract:BACKGROUND:To develop evolutionary models for the free living bacterium Alteromonas the genome sequences of isolates of the genus have been extensively analyzed. However, the main genetic exchange drivers in these microbes, conjugative elements (CEs), have not been considered in detail thus far. In this work, CEs have ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-3461-0
更新日期:2017-01-05 00:00:00